Evaluation of Antihyperglycemic and Hypolipidemic Action of Euphorbia Caducifolia Latex Powder on Alloxan-Induced Diabetic Rats

Background: The study of Plants having antihyperglycaemic and hypolipidaemic activities may give new approach in the treatment of diabetes with lesser side effects. Objective: The study was intended to evaluate the antihyperglycemic and hypolipidemic action of Euphorbia caducifolia latex powder in alloxan-induced Diabetic Rats. Materials and Methods: Diabetes was induced in albino rats by using alloxan monohydrate (150 mg/kg). Rats were divided into five groups of six animals each. First group served as non-diabetic control, second group as diabetic control, third group as standard and was treated with Nopal. Group 4 and 5 received 100 and 200 mg/kg body weight of ECLP. Blood samples were analyzed for blood glucose on day 1, 7, 14 and lipid profile on day 21. Results: The ECLP showed significant reduction (P<0.01) in blood glucose level and serum lipid profile levels with 200 mg/kg body weight in alloxan-induced diabetic rats as compared with the control. Conclusion: It is concluded that ECLP is effective in controlling blood glucose levels and in improving lipid profile in diabetic rats. Keywords— Alloxan, Antihyperglycemic, Diabetes Mellitus, Hypolipidemic.