Influence of Mangos on Vascular Function and Platelet Reactivity in Postmenopausal Women University of California , Davis Submitted to the National Mango Board Final report January 30 , 2018 Collaborators

Mangos are rich in mangiferin, a phenolic acid that has multiple bioactive effects. Combined with carotenoids, fiber and other nutrients, mangos may be of benefit to vascular health. This study assessed whether a short-term (14 days) or acute (two hours) intake of mangos can influence: 1) microvascular function and the augmentation index, determined by peripheral arterial tonometry; 2) blood pressure; 3) optical platelet aggregometry, and 4) gut fermentation, determined by breath hydrogen and methane, in healthy adult women. 25 healthy postmenopausal females (BMI 25-40 kg/m) were assessed at three study visits. Study visit 1 (SV1) started a run-in period of 14 d during which no mangos were consumed, with baseline and two-hour measures taken. At study visit 2 (SV2), baseline (0 hour) measures were taken, followed by ingestion of 300 gm (two cups) of fresh, frozen mangos, and data were collected two hours later. Participants then consumed 300 g of mangos daily for 14 days, followed by assessment at study visit 3 (SV3), which followed the same protocol as SV2. Breath samples were collected at baseline at each study visit.