Amyloid Precursor Protein Controls Neuronal Cholesterol Turnover Needed For Synaptic Activity

Thank you for the submission of your manuscript "Amyloid Precursor Protein Controls Neuronal Cholesterol Turnover Needed For Synaptic Activity" and please accept my apologies for the delayed reply. We have now finally heard back from the three referees whom we asked to evaluate your manuscript. As you will see, the referees acknowledge that the overall topic of the manuscript is potentially interesting and reviewer #2 is rather positive about the manuscript. However, reviewers #1 and #3 are much more reserved and raise significant concerns, which, I am afraid, preclude publication of the manuscript in EMBO Molecular Medicine.