Plk 4 : prognostic markers , drivers of breast tumorigenesis and drug resistance

1. Abstract 2. Introduction 3. Nek2, Plk4 and centrosome amplification in breast cancer 3.1. Nek2 and Plk4 in breast tumors and experimental models 3.2. Centrosome amplification in breast cancer 4. Nek2 and Plk4 as prognostic markers 5. Novel roles for Nek2 and Plk4 in breast cancer 5.1. Nek2 and Plk4: drivers of breast tumorigenesis 5.2. Drug resistance 6. Perspectives and clinical impact 7. Acknowledgments 8. References