Sirtuin Inhibition prevents macrophage self-renewal

As you can see below, while the referees find the analysis potentially interesting they also find it too preliminary at this stage for consideration here. The referees raise different issues with the analysis that are clearly outlined below. Among some of the points raised are that as NAM can inhibit other enzymes like PARP that further data supporting the key role of SIRT1 in this process is needed. Referee #3 also finds that more in vivo data is needed to support the main conclusions. Given the comments raised I am afraid that I can't offer to consider publication here.