TET 1 Is Decreased in Human Prostate Cancer Tissues and Implanted Prostate Cancer Cells Metastasized from Mouse Prostate to Lung

Chih-Hung Hsu,1,11,13 Kai-Lin Peng,1,2,11 Ming-Lun Kang,1,12 Yi-Ren Chen,3,12 Yu-Chih Yang,3 Chin-Hsien Tsai,3,4 Chi-ShuenChu,1,5 Yung-Ming Jeng,6 Yen-TingChen,1,5 Feng-MaoLin,7 Hsien-DaHuang,7 Yun-Yuh Lu,1 Yu-Ching Teng,1,2 Shinn-Tsuen Lin,8 Ruo-Kai Lin,1,14 Fan-Mei Tang,9 Sung-Bau Lee,1,15 Huan Ming Hsu,10 Jyh-Cherng Yu,10,* Pei-Wen Hsiao,3,* and Li-Jung Juan1,2,5,* 1Genomics Research Center, Academia Sinica, Taipei 115, Taiwan, ROC 2Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan, ROC 3Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan, ROC 4Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan, ROC 5Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan, ROC 6Graduate Institute of Pathology, National Taiwan University, Taipei 100, Taiwan, ROC 7Department of Biological Science and Technology, Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan, ROC 8R&D department, GeneTex Asia Ltd, Hsinchu 300, Taiwan, ROC 9Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, ROC 10DivisionofGeneralSurgery,Department ofSurgery, Tri-ServiceGeneralHospital,NationalDefenseMedicalCenter, Taipei 114, Taiwan,ROC 11These authors contributed equally to this work 12These authors contributed equally to this work 13Present address: Division of Newborn Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA 14Present address: Graduate Institute of Pharmacology, Taipei Medical University, Taipei 110, Taiwan, ROC 15Present address: Biotech Research and Innovation Centre (BRIC), University of Copenhagen, DK2200 Copenhagen, Denmark *Correspondence: doc20106@ndmctsgh.edu.tw (J.-C.Y.), pwhsiao@gate.sinica.edu.tw (P.-W.H.), ljjuan@gate.sinica.edu.tw (L.-J.J.) http://dx.doi.org/10.1016/j.celrep.2012.08.030