3D Primary Human Hepatocytes (PHH) Spheroids Demonstrate Increased Sensitivity to Drug-induced Liver Injury in Comparison to 2D PHH Monolayer Culture

Despite the use of in silico, in vitro, and preclinical animal models for liver safety assessment during drug discovery and development, Drug-induced Liver Injury (DILI) remains a leading cause of drug attrition, post-marketing withdrawals, and restrictive usage warnings1. Therefore, researchers are continuously exploring novel liver models that can faithfully recapitulate the physiology and biology of the human liver2.