P 053 Cannabinoid 2 Receptor Modulation In The Iris Microcirculation During Experimental Endotoxemia

Introduction: Endotoxemia produces systemic leukocyte activation [1]. In the iris, the interaction of activated leukocytes with the vascular endothelium can result in ocular inflammation (uveitis) and cause tissue damage. The endocannabinoid system is involved during systemic inflammation [2] and cannabinoid drugs that interact with endogenous cannabinoid receptors (CB1R and CB2R) have immunomodulatory properties in experimental studies [3]. However, the effects of modulating the endocannabinoid system in the iris during acute endotoxemia are currently unknown. The aim of this study, therefore, was to examine the impact of CB2R modulation on leukocyte activation during experimental endotoxemia using intravital microscopy (IVM).