Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF-1 R activation Running title : Irradiated CAF promote tumor progression

Joke Tommelein , Elly De Vlieghere , Laurine Verset, Elodie Melsens , Justine Leenders, Benedicte Descamps, Annelies Debucquoy, Christian Vanhove, Patrick Pauwels, Christian P. Gespach, Anne Vral, Astrid De Boeck, Karin Haustermans, Pascal de Tullio, Wim Ceelen , Pieter Demetter, Tom Boterberg , Marc Bracke , Olivier De Wever * Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium Cancer Research Institute Ghent (CRIG), Ghent, Belgium Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium Department of Surgery, Ghent University Hospital, Ghent, Belgium Center for Interdisciplinary Research on Medicines (CIRM), Université de Liège, Liège, Belgium Department of Electronics and Information System, iMinds-IBiTech-MEDISIP, Ghent University, Ghent, Belgium 7 KU Leuven, University of Leuven, Department of Oncology, Experimental Radiotherapy; University Hospitals Leuven, Radiation Oncology, Leuven, Belgium Center for Oncological Research (CORE), University of Antwerp, Antwerp, Belgium Institut National de la Santé et de la Recherche Médicale, INSERM U938, Molecular and Clinical Oncology, Université Paris VI Pierre et Marie Curie, Paris, France Department of Basic Medical Sciences, Physiology Group, Ghent University, Ghent, Belgium Arnie Charbonneau Cancer Centre, University of Calgary, Calgary, AB, Canada