Sleep-Wake Regulation Poster N ° 1 Cold-Inducible RNA Binding Protein ( CIRBP ) contributes to quality of waking , REM sleep homeostasis and refines the molecular response to sleep deprivation ( SD )

Objectives: SD changes clock-gene expression but the underlying mechanism is unknown. We propose CIRBP because 1) its expression is sleep-wake driven, possibly through changes in cortical temperature (Tcx); 2) CIRBP mediates highamplitude clock-gene expression. We therefore expect that sleep-wake dependent changes in clock-gene expression are attenuated in CIRBP knock-out (KO) mice, thereby altering the sleep homeostat.