Cancer Therapy : Preclinical Anti-DLL 4 HasBroad SpectrumActivity in Pancreatic Cancer DependentonTargetingDLL 4-NotchSignaling inBothTumor and Vasculature Cells

Wan-Ching Yen,Marcus M. Fischer,Mark Hynes,Jingjiang Wu,Edward Kim, Lucia Beviglia,V. Pete Yeung,Xiaomei Song,Ann M. Kapoun,John Lewicki,Austin Gurney, Diane M. Simeone,Timothy Hoey

semanticscholar（2012）

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摘要

Purpose: We previously showed that targeting Delta-like ligand 4 (DLL4) in colon and breast tumors inhibited tumor growth and reduced tumor initiating cell frequency. In this report, we have extended these studies to pancreatic cancer and probed the mechanism of action in tumor and stromal cells involved in

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