Fitness Costs for Influenza B Viruses Carrying Neuraminidase Inhibitor-Resistant 1 Substitutions : Underscoring the Importance of E 119 A and H 274 Y 2 3 4

Fitness Costs for Influenza B Viruses Carrying Neuraminidase Inhibitor-Resistant 1 Substitutions: Underscoring the Importance of E119A and H274Y 2 3 4 Andrew J. Burnham, Tatiana Baranovich, Bindumadhav M. Marathe, Jianling Armstrong, 5 Robert G. Webster, and Elena A. Govorkova* 6 7 Department of Infectious Diseases, St. Jude Children’s Research Hospital, 262 Danny Thomas 8 Place Memphis, Tennessee, 38105-3678, USA 9 Running Title: NAI–resistant mutations in influenza B viruses 10 11