Synthesis Antimicrobial Activity and Chemotherapeutic Potential some Novel Benzimidazole Derivatives

Benzimidazole derivates play vital role in biological field such as antimicrobial, antiviral, antidiabetic, and anticancer activity. Therapeutic significance of these clinically useful drugs in treatment of microbial infections encouraged the development of some more potent and significant compounds. With the purpose of finding new chemical entities with enhanced antimicrobial activity, a series comprises 2-substituted-5-nitro benzimidazole derivatives were synthesized. Investigation of antimicrobial activity of the compounds was done by disc diffusion method using Gram-positive (S. aureus, S. mutans and B. subtilis), Gram-negative (E. coli, S. typhi and P. aeruginosa) bacteria. Some derivatives showed remarkable activity comparable to that of standard against Gram-positive and Gram-negative bacteria.