Revised version 2 ) Biallelic DICER 1 mutations in sporadic pleuropulmonary blastoma Running title Biallelic DICER 1 mutations in sporadic PPB

Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Laboratory of Sequence Data Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Pediatric Hematology and Oncology, Ibaraki Children’s Hospital, Mito, Ibaraki, Japan; Department of Hematology/Oncology, Saitama Children’s Medical Center, Saitama, Saitama, Japan; Department of Cell Therapy and Transplantation Medicine, The University of Tokyo, Tokyo, Japan; Department of Pediatrics, School of Medicine, Fukuoka University, Fukuoka, Fukuoka, Japan; Gunma Children’s Medical Center, Shibukawa, Gunma, Japan; Department of Hematology and Oncology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Hyogo, Japan; National