1 Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte 1 2

Yu Sasaki 1 , Teruo Hidaka 1 , Takashi Ueno 2 , Miyuki Akiba-Takagi 1 , Juan Alejandro Oliva Trejo 1,3 , 3 Takuto Seki 1,3 , Yoshiko Nagai-Hosoe 1 , Eriko Tanaka 1,4 , Satoshi Horikoshi 1 , Yasuhiko Tomino 1 , 4 Yusuke Suzuki 1 and Katsuhiko Asanuma 1,3,* 5 1 Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of 6 Medicine, Tokyo, Japan 7 2 Laboratory of Proteomics and Biomolecular Science, Research Support Center, Juntendo 8 University Graduate School of Medicine, Tokyo, Japan 9 3 Medical Innovation Center, TMK project, Graduate School of Medicine, Kyoto University, 10 Kyoto, Japan 11 4 Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo 12 Medical and Dental University, Tokyo, Japan 13 14 15 Correspondence: *Katsuhiko Asanuma MD, PhD 16 Medical Innovation Center, TMK Project, Kyoto University Graduate School of Medicine, 17 53 Shogoin Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan 18 Tel: +81-75-366-7437 19 E-mail: asanuma@tmk.med.kyoto-u.ac.jp 20