LKB1 inhibits intrahepatic cholangiocarcinoma by repressing the transcriptional activity of the immune checkpoint PD-L1.

Zhuo Liu,Shaojie Li,Jian Zeng,Xin Zhou, Huangyu Li,Xiang Liu,Feng Li,Bin Jiang,Ming Zhao,Tiexiang Ma

Life Sciences（2020）

引用 8|浏览4

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摘要

By suppressing malignant transformation and the immune checkpoint PD-L1 of cancer cells, LKB1 plays an important role in inhibiting ICC and is a potential target for clinical diagnosis and treatment. This study may provide new strategies for improving the efficiency of cancer immunotherapy.

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关键词

Intrahepatic cholangiocarcinoma,LKB1,EMT,PD-L1,Transcriptional activity

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