The correlation between Helicobacter Pylori infection, hyperemesis gravidarum and anaemia among pregnant females - effect of treatment

Objective: The aim of this study was to detect the relationship between Helicobacter pylori (H.pylori) infection and pregnancy related disorders: anemia and hyperemesis gravidarum. Study Design: It was a prospective study. Randomized control study. Patients and methods: In our study pregnant women between 6-12 weeks of gestation were divided into 3 groups: control group of 144 patients, hyperemesis gravidarum group of 88 patients, anemia group of 128 patients. Seropositivity for H.pylori was studied in each group. H.pylori positive patients in anemia group were divided into two groups and asked to return in second trimester and one group of them recieved treatment of anemia alone, while the other one recieved treatment of anemia and H.pylori treatment and the change in hemoglobin (Hb) levels was detected in both groups Results: The percentage of H.pylori seropositive patients in the control group was 45.8%, in hyperemesis group 86.4% while in the anemia group was 84.4% (p value< 0.001).The change in Hb in the group which was given treatment of anemia alone was 0.936± 0.325 while it was 1.438± 0.354 in the group which was given treatment for anemia plus treatment to eradicate H.pylori (P value <0.001). Conclusions: Our study showed strong association between H.pylori infection and hyperemesis gravidarum and we suggested screening of H.pylori in cases with hyperemesis especially in severe cases. And we founded great benefit in eradication of H.pylori infection with treatment of anemia in pregnant women.