Structures of C 1 q-like Pro teins Reveal Unique Features among the C 1 q / TNF Superfamily Graphical Abstract Highlights

In Brief C1q-like-1, -2, and -3 proteins bind to brain-specific angiogenesis inhibitor 3, an adhesion-type G-protein coupled receptor that may regulate dendritic morphology by organizing actin filaments. Ressl et al. report highresolution crystal structures of the C1QL protein family. The structures reveal unique features among the C1q/TNF superfamily that are likely associatedwith their specific brain functions.