Metabolic Symbiosis Enab les Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent onmTOR Signaling Graphical

In Brief Allen et al. find that inhibitors of tumor angiogenesis that cause acute hypoxia elicit compartmentalization of cancer cells into symbiotic clusters. Hypoxic cancer cells metabolize glucose and secrete lactate; normoxic, vesselproximal cancer cells import and metabolize the lactate in a process involving mTOR signaling. Co-inhibition of mTOR disrupts the symbiosis, in part by upregulating glucose transport in normoxic cells.