Myc drives Pten / p 53-deficient proliferation and metastasis due to Il 6-secretion and Akt-suppression via Phlpp 2 RUNNING TITLE : Il 6 drives Myc in Pten-mutant prostate metastasis

RUNNING TITLE: Il6 drives Myc in Pten-mutant prostate metastasis Dawid G. Nowak, Hyejin Cho , Tali Herzka , Kaitlin Watrud, Daniel V. DeMarco, Victoria M.Y. Wang, Serif Senturk, Christof Fellmann, David Ding, Tumas Beinortas, David Kleinman, Muhan Chen, Raffaella Sordella, John E. Wilkinson, Mireia Castillo-Martin, Carlos Cordon-Cardo, Brian D. Robinson & Lloyd C. Trotman* 1 Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724 2 Mirimus Inc., 1 Bungtown Road, Cold Spring Harbor, NY 11724 3 Department of Pathology, University of Michigan, Ann Arbor, MI 48109 4 Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029 5 Department of Pathology, NewYork-Presbyterian Hospital, Weill Cornell Medical College, New York, NY 10065 # equal contribution * correspondence: trotman@cshl.edu The authors disclose no potential conflicts of interest