The isolated armadillo-repeat domain of Plakophilin 1 is a monomer in solution with a low conformational stability.

A Marcela Giudici,José G Hernández-Cifre,Ana Cámara-Artigas,Felipe Hornos,Sergio Martínez-Rodríguez,Juan Carlos Alvarez-Pérez, Inés Díaz-Cano,María Esther Fárez-Vidal,José L Neira

Journal of Structural Biology（2020）

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摘要

•The isolated armadillo domain of plakophilin 1 (ARM-PKP1) is a monomer in solution.•The ARM-PKP1 has a low thermal stability on a narrow pH range.•The presence of redox agents did not alter either the structure or the stability of ARM-PKP1.•ARM-PKP1 unfolded through several intermediates.

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关键词

ANS,ARM,ARM-PKP1,CD,DLS,DSC,GdmCl,MW,PKP,TCEP,UV

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