Genetic Polymorphisms Ininterleukin-6andinterleukin-1-Betawere Associated With Dental Caries And Gingivitis

Objective Evaluate the association between single nucleotide polymorphisms (SNPs) inInterleukin-6(IL-6) gene (rs1800795) and inInterleukin-1-beta(IL-1 beta) gene (rs1143627 and rs1143629) with dental caries and gingivitis in Brazilian children. Material and methods Three hundred and fifty-three children aged 8-11 years were included. Visible biofilm and gingival bleeding were evaluated by Community Periodontal Index. The International System for Detection and Assessment of Carious Lesions (ICDAS) was used to investigate dental caries. Real-time PCR evaluated SNPs in the DNA. Chi-square test, haplotype analysis and logistic regression were applied (alpha of 5%). Results The GG genotype in rs1800795 (IL-6) decreases the risk of gingivitis in a co-dominant model (p = .05; OR = 0.64). The GG genotype in rs1143627 (IL-1 beta) reduces the risk of dental caries (Co-dominant model: ICDAS(0)versus ICDAS(1-6):p = .05; OR = 0.55. ICDAS(0-2)versus ICDAS(3-6):p = .02; OR = 0.49. Recessive model: ICDAS(0)versus ICDAS(1-6):p = .005; OR = 0.48. ICDAS(0-2)versus ICDAS(3-6):p = .004; OR = 0.45. Logistic regression: ICDAS(0-2)versus ICDAS(3-6):p = .05; OR = 0.24; CI 95%= 0.05-1.00). The GG genotype in rs1143629 was more frequent in ICDAS(0)(p = .05; OR: 0.60). In the haplotype analysis,IL-1 beta was associated with gingivitis. Conclusion The rs1800795 inIL-6gene was associated with gingivitis. The rs1143627 and rs1143629 inIL-1 beta were associated with dental caries and gingivitis.