Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples.

Sharon Berendsen,Elselien Frijlink,Jèrôme Kroonen,Wim G M Spliet,Wim van Hecke,Tatjana Seute,Tom J Snijders,Pierre A Robe

Neuro-oncology advances（2019）

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摘要

The in vitro effects of VPA on histone acetylation status in glioblastoma cells could not be confirmed in clinical tumor samples of glioblastoma patients using antiepileptic doses of VPA, which reflects the lack of effect of VPA on the clinical outcome of glioblastoma patients.

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关键词

glioblastoma,histone deacetylase inhibition,in vitro,in vivo,valproic acid

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