Sexually dimorphic impact of the iron-regulating gene, HFE , on survival in glioblastoma.

Darya S Nesterova,Vishal Midya,Brad E Zacharia,Elizabeth A Proctor,Sang Y Lee,Lindsay C Stetson,Justin D Lathia,Joshua B Rubin,Kristin A Waite,Michael E Berens,Jill S Barnholtz-Sloan,James R Connor

Neuro-oncology advances（2020）

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摘要

The level of expression in GBM has a sexually dimorphic impact on survival. Whereas expression below the median imparts a survival benefit to females, high expression is associated with significantly worse overall survival regardless of established prognostic factors such as sex or MGMT methylation.

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关键词

HFE,glioblastoma,iron,sex,tumor

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