Introductory Histopathological Findings May Shed Light On Covid-19 Paediatric Hyperinflammatory Shock Syndrome

Numerous pediatric cases of hyperinflammatory shock syndrome (demonstrating features reminiscent of Kawasaki vasculitis) were recently associated with infection by COVID-19. Clinical presentation includes unrelenting fever, variable rash, conjunctivitis and abdominal pain, progressing to hemodynamic shock with severe myocardial involvement. Recent report from Italy reported a 30 time increase in the rate of Kawasaki-like presentation during the COVID-19 pandemic among children, In many cases the nasopharyngeal swabs taken from these children were negative for COVID-19, and the association with COVID-19 infection is unclear.