Haplotype Networks Of Sars-Cov-2 Infections In The Diamond Princess Cruise Ship Outbreak
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA(2020)
摘要
The Diamond Princess cruise ship was put under quarantine off-shore Yokohama, Japan, after a passenger who disembarked in Hong Kong was confirmed as a coronavirus disease 2019 case. We performed whole-genome sequencing of severe acute respira-tory syndrome coronavirus 2 (SARS-CoV-2) directly from PCR+ clin-ical specimens and conducted a phylogenetic analysis of the outbreak. All tested isolates exhibited a transversion at G11083T, suggesting that SARS-CoV-2 dissemination on the Diamond Prin-cess originated from a single introduction event before the quar-antine started. Although further spreading might have been prevented by quarantine, some progeny clusters could be linked to transmission through mass-gathering events in the recreational areas and direct transmission among passengers who shared cab-ins during the quarantine. This study demonstrates the usefulness of haplotype network/phylogeny analysis in identifying potential infection routes.
更多查看译文
关键词
SARS-CoV-2,COVID-19,Diamond Princess,haplotypes
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要