To Explore the Potential Mechanism of Yiqing Capsule in the Treatment of COVID-19 Based on Network Pharmacology

Objective: To\r\nselect the ingredients and targets of Yiqing capsule in treating COVID-19 based\r\non network pharmacology, then to explore the potential mechanism of Yiqing\r\ncapsule in treating COVID-19. Methods: We screened\r\nthe ingredients and targets of Yiqing capsule on Traditional Chinese Medicine\r\nSystems Pharmacology Database and Analysis Platform (TCMSP), and target genes\r\nfor COVID-19 in GeneCards database, constructed drug-ingredient-target network through software Cytoscape 3.7.2, and constructed protein protein interaction network (PPI) network through\r\nSTRING database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia\r\nof Genes and Genomes (KEGG) analysis of key gene targets of Yiqing capsule are used to treat\r\nCOVID-19 through software R5.3.2. Results: We got 42 ingredients, 42 potential therapeutic targets, 1643 GO items\r\nand 970 pathways in our study. The main pathway including IL-17 signaling\r\npathway, Chagas disease (American trypanosomiasis), Influenza A, and TNF\r\nsignaling pathway. Conclusion: Yiqing capsule plays a role in treating COVID-19 through multiple\r\ningredients, multiple targets and multiple pathways.