Sensitivity of commercial Anti-SARS-CoV-2 serological assays in a high-prevalence setting
medRxiv(2020)
摘要
We analysed SARS-CoV-2 specific antibody responses in 42 social and working contacts of a super-spreader from the Heinsberg area in Germany. Consistent with a high-prevalence setting 26 individuals had SARS-CoV-2 antibodies determined by in-house neutralisation testing. These results were compared with four commercial assays, suggesting limited sensitivity of the assays in such a high-prevalence setting. Although SARS-CoV-2 nucleocapsid restricted tests showed a better sensitivity, spike based assays had a stronger correlation with neutralisation capacity.
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关键词
serological assays,high-prevalence high-prevalence,anti-sars-cov
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