Clinical Characteristics Of Concurrent Primary Aldosteronism And Renal Artery Stenosis: A Retrospective Case-Control Study

Background Rare cases of concurrent primary aldosteronism (PA) and renal artery stenosis (RAS) have been reported. Methods In this retrospective case-control study, we selected a cohort of 10 PA with RAS patients and a control group of 20 PA without RAS patients from January 1, 2006, to January 1, 2016. Results All patients presented with refractory hypertension, and a nonstatistically significant trend toward lower mean serum potassium was seen in the PA with RAS group (p =.07). PA with RAS patients had lower mean orthostatic aldosterone-to-renin ratios (38.4 +/- 41.4 ng dL(-1)/ng mL(-1) h(-1) vs. 87.4.4 +/- 38.4 ng dL(-1)/ng mL(-1) h(-1), respectively; p < .01) and a higher false-negative rate (50% vs. 15%, respectively; p < .05) compared with controls. All misdiagnosed patients had the diagnosis of PA confirmed when we revaluated the repeated screening and confirmative tests because of residual hypertension or hypokalemia after successful revascularization of renal artery stenosis. Conclusions PA is easily missed in patients with RAS because of the high false-negative rate for screening tests. RAS patients with residual hypertension after successful renal angioplasty should be monitored for coexisting PA. Reevaluation of screening and confirmatory tests is helpful in establishing the correct diagnoses.