Voltage-dependent modulation of TRPA1 currents by diphenhydramine.

Xianfeng Shen,Qiaochu Wang,Yakang Lin,Koti Sreekrishna,Zhiyuan Jian,Michael X Zhu,Jinbin Tian

Cell Calcium（2020）

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摘要

•Diphenhydramine potentiates human TRPA1 currents at negative potentials.•Diphenhydramine suppresses human and mouse TRPA1 currents at positive potentials.•Diphenhydramine suppresses both inward and outward currents of TRPV1.•Diphenhydramine’s action on TRPA1 and TRPV1 may underlie some of its therapeutic effects.

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关键词

15d-PGJ2,AITC,DPH,ECS,FFA,G-V,I-V,NMDG,PEI

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