CARs need a jump start to get going
NATURE IMMUNOLOGY（2020）
摘要
CAR T cells are engineered to recognize tumor-specific antigens and kill tumor cells. A study of CAR T cell activation using single-molecule microscopy reveals that CARs fail to efficiently convert antigen binding into early T cell signaling events.
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关键词
Immunotherapy,Signal transduction,Biomedicine,general,Immunology,Infectious Diseases
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