Iron chelation promotes 5-aminolaevulinic acid-based photodynamic therapy against oral tongue squamous cell carcinoma

Jiaqi Qin,Ce Zhou,Mengqi Zhu,Shurui Shi,Lianyun Zhang,Yanhong Zhao,Changyi Li,Yinsong Wang,Yue Wang

Photodiagnosis and Photodynamic Therapy（2020）

引用 6|浏览40

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摘要

•Deferasirox greatly enhanced the accumulated PpIX in 5-ALA-treated OTSCC cells through iron chelation.•Deferasirox promoted 5-ALA-based PDT against OTSCC both in vitro and in vivo.•Combination of 5-ALA-based PDT with iron chelation maybe a promising strategy for OTSCC therapy.

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关键词

5-Aminolaevulinic acid,Deferasirox,Photodynamic therapy,Iron chelation,Oral tongue squamous cell carcinoma

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