Stimulation with FITC-labeled antigens confers B cells with regulatory properties

Cyril Planchais,Julie Rayes,Sandrine Delignat,Shina Pashova, Aditi Varthaman,Anastas Pashov,Jagadeesh Bayry,Srinivas V. Kaveri,Jordan D. Dimitrov,Sebastien Lacroix-Desmazes

Cellular Immunology（2020）

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摘要

•Fluorescein isothiocyanate (FITC) binds to ~20% of splenic B cells from naïve mice.•Binding of antigen-coupled FITC to B cells induces IL-10 production and antigen endocytosis.•OVA-FITC loaded B cells polarizes OTII T cells towards a Tr1/Th2 phenotype.•MOG-FITC-loaded B cells protects mice from EAE upon adoptive transfer.

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关键词

Immuno-modulatory B cells,IL-10,Experimental autoimmune encephalitis

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