The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice.

Alana Gessica Amaral Santos,Luiza Aparecida Ansaloni Chagas Pereira,Joao Henrique Moreira Viana,Remo Castro Russo,Paulo Henrique Almeida Campos-Junior

Journal of Reproductive Immunology（2020）

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摘要

•CC-chemokine Receptor 2 is expressed by oocytes included in growing follicles.•CCR2 deficiency attenuates ovarian follicles activation and atresia in adult mice.•Genetic ablation of CCR2 prolongs ovarian lifespan.•CCR2 regulates ovarian follicular activation and atresia.

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关键词

Ovary,CCR2,Follicle,Aging,Fertility

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