Structural and dynamic asymmetry in icosahedrally symmetric virus capsids.
Current Opinion in Virology(2020)
摘要
•Symmetry breaking events in icosahedral viruses are important for infection.•Advances in cryo-EM technology has enabled asymmetric virus structure determination.•Current MD simulations can compute full capsid dynamics on ns–μs timescales.•Further integration of modeling and experimental data will advance drug discovery.
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