Low-Bias Amplification for Robust DNA Data Readout

Yanmin Gao
Yanmin Gao
Xin Chen
Xin Chen
Chengwei Zhang
Chengwei Zhang
Hongyan Qiao
Hongyan Qiao
Yonggang Ke
Yonggang Ke
Hao Qi
Hao Qi

bioRxiv, 2020.

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Abstract:

In DNA data storage, the massive sequence complexity creates challenges in repeatable and efficient information readout. Here, our study clearly demonstrated that canonical polymerase chain reaction (PCR) created significant DNA amplification biases, which greatly hinder fast and stable data retrieving from hundred-thousand synthetic DNA ...More

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