The Design of a Respiratory Rate Mobile Application

» In closed-loop control of anesthesia• drug infusion rates are automatically adjusted using continuous feedback from a measure of clinical effect1• safety constraints based on the drug’s known therapeutic window are required to avoid under/overdosing2» For closed-loop propofol administration, we limit the predicted effect site concentration (Ce) to [1.5 mcg/ml-8 mcg/ml], based on the Schnider pharmacokinetic (PK) model3» A recently published general purpose PK model for propofol4 suggests the Schnider model underestimates drug concentrations» Objective: We examine the incidence of reaching the lower safety bound for propofol with our current system, and compare the predicted plasma concentrations (Cp) of the Schnider model3 to those of the general purpose PK model4