Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.

Degang Wu,Niansheng Lai,Ruming Deng,Tianyu Liang,Pengjie Pan,Guiqiang Yuan,Xiang Li,Haiying Li,Haitao Shen,Zhong Wang,Gang Chen

Experimental Neurology（2020）

引用 16|浏览16

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摘要

•Protein levels of WNK3 increased significantly in brain tissues after ICH.•Decreasing of WNK3 played neuroprotective effects in rats after ICH.•Inhibition of WNK3 decreased OxyHb-induced neuronal apoptosis in vitro.•WNK3 participated in ICH-induced secondary brain injury.

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关键词

WNK3,Intracerebral hemorrhage,Secondary brain injury,Cell apoptosis,Brain edema

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