Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones

Ying Cheng,Huiqin Zhang,Lejing Qu,Ying He,Michael N Routledge,Yun Yun Gong,Boling Qiao

Food Chemistry（2020）

引用 28|浏览9

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摘要

•Rats fed with rhubarb anthraquinones (RA) showed colonic toxicity.•The RA metabolites in the feces were investigated by HPLC.•The metabolite rhein accumulated in RA-rat feces.•Fecal flora of the RA-rats biotransformed sennoside A to rhein.•Rhein induced apoptosis and autophagy in normal colon cells.

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关键词

FFS,H&E,HPLC,MC,NC,RA,SA,SD,SRB

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