Population pharmacokinetic/pharmacodynamic modeling for remimazolam in the induction and maintenance of general anesthesia in healthy subjects and in surgical subjects.

•PK-PD used to find remimazolam dose in general anesthesia for weight-based regimen.•Most covariate effects were small and did not change the dosing recommendations.•No dose adjustments required; but consider dose reduction in medically complex elderly patients.•Consider dose reduction in ASA Class 3 patients with significant disease burden.