The effect of olmesartan on aortic intimal thickening after balloon injury through Apelin/APJ.

Yonghong Li,Junjie Guo,Haichu Yu,Jingwei Zhou,Xianming Chu,Bo Hou,Junhua Ge,Tingting Li, Shuo Duan,Hui Xu,Xi Yang

Cardiovascular Pathology（2020）

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摘要

•Ang II, AT1, Apelin and APJ mRNA were promoted by vascular balloon injury.•Olmesartan decreased the proliferation of VSMC and the intimal thickening.•Olmesartan inhibits the intimal thickening through activating Apelin/APJ.

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关键词

Ballooninjury,Apelin,APJ,Extracellularsignalregulatedkinase,Olmesartan

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