COVID-19 pneumonia: CD8 + T and NK cells are decreased in number but compensatory increased in cytotoxic potential.

Yujie Jiang,Xin Wei,Jingjing Guan,Shuang Qin,Zhongyong Wang,Hong Lu,Jingjing Qian,Lianfeng Wu,Yingxiao Chen,Yanfan Chen,Xiangyang Lin

Clinical Immunology（2020）

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摘要

•As disease progression, CD8+ T and NK cells were decreased but highly activated.•After effective treatment, the immune status of CD8+ T and NK cells restored.•GrA+ CD8+ T and perforin+ NK cells could assist diagnosis of COVID-19.

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关键词

COVID-19,CD8+ T cells,NK cells,Perforin,Granzyme

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