Rom2-dependent phosphorylation of Elo2

Background: Sphingolipids are synthesized from very long chain fatty acids and sphingoid bases.Results: Rom2 controls Elo2 phosphorylation to regulate very long chain fatty acid synthesis.Conclusion: Distinct signaling pathways emanating from the plasma membrane regulate the different branches of sphingolipid synthesis.Significance: Signaling from the plasma membrane regulates a key step in sphingolipid synthesis, required for lipid homeostasis of the plasma membrane.Abstract: