Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature

Melanie R. Hassler,Freddie Bray,James W.F. Catto,Arthur P. Grollman,Arndt Hartmann,Vitaly Margulis,Surena F. Matin,Morgan Roupret,John P. Sfakianos,Shahrokh F. Shariat,Bishoy M. Faltas

European Urology（2020）

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摘要

Recent data obtained by high-throughput molecular profiling technologies underscore the distinct molecular alterations found in upper tract urothelial carcinoma (UTUC). UTUC biology shares many features with bladder cancer, but there are important specific distinctions that support the need for UTUC-targeted therapeutic strategies.

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关键词

Urothelial carcinoma,Renal pelvis,Ureter,Genomics,Next-generation sequencing,RNAseq,Transcriptomics,Proteomics,Molecular alterations,Molecular characterization

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