A Rare Case Of Splenicpneumocystis Jiroveciiin A Hiv-Positive Patient

Introduction. Human immunodeficiency virus (HIV) positive individuals with the CD4 count less than 200 cells/mm(3)are at risk for opportunistic infections.Pneumocystis jirovecii, a fungal pathogen, is a common cause of opportunistic infections with predominantly pulmonary involvement. DisseminatedP. jiroveciiiinfection presenting with hepatosplenic lesion is extremely rare.Case Summary. A 31-year-old male with HIV with and acquired immunodeficiency syndrome (AIDS) presented with diarrhea for 3 weeks. He had splenomegaly and inguinal lymphadenopathy on physical examination. Laboratory parameters revealed anemia and hypoalbuminemia, while stool studies for infectious etiology and fecal leucocyte were negative. Computed tomography (CT) of the chest and abdomen depicted consolidation of the lungs and a large splenic mass. He underwent fiberoptic bronchoscopy with transbronchial biopsy which was consistent withP. jiroveciipneumonia. He also had a ultrasound-guided core biopsy of the splenic mass which revealed necrotizing granulomas withPneumocystis jiroveciiinfection on Grocott-Gomori's methenamine silver (GMS) stain and was initiated on treatment forP. jiroveciiwith sulfamethoxazole with trimethoprim.Conclusion. Malignancy and atypical infection are key differentials in patients presenting with hepatosplenic lesions. HIV positive patients are at increased risk of AIDS-related lymphoma. Tissue diagnosis is often required for further evaluation. DisseminatedP. jiroveciipresenting with splenic mass and liver lesion is extremely rare.