Molecular Taxonomy of Meningioma: A169.

Background: Meningiomas, as the most common primary brain tumor in adults, are undergoing a reawakening in biological understanding. An increasing array of genomic and epigenetic studies has unveiled a cascading array of molecular signatures for meningiomas, with prognostic and phenotypic implications. Among these, aggregates of chromosomal alterations and methylation profiles may portend meningioma recurrence beyond the scope of current histopathologic criteria. However, a rigorous molecular scheme for determination of meningioma behavior, with long-term clinical annotation and outcomes and which is widely accessible to clinicians, is still lacking.Methods: We analyzed 530 meningiomas from patients who underwent surgical resection between 1999 and 2017 (350 women and 180 men; mean age= 72.5 years) and whose tumors were analyzed by high-resolution array comparative genomic …