Poly (acrylic acid) (PAA) is a contact system activator with properties to stop hemorrhage.

Gabriel L. Forbes,Alona Merkulova, Alexandro Pinheiro,Jasmine Lee,Peng Zeng,Sarah Abdalian,Anne Y. Walker,Gary E. Wnek,Alvin H. Schmaier

Thrombosis Research（2020）

引用 6|浏览0

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摘要

•Poly(acrylic acid) (PAA) is an inexpensive, nontoxic, durable, negatively charged material.•PAA supports factor XII autoactivation and thrombin generation in plasma.•PAA-impregnated filter paper reduces blood loss by 22 to 40% in two murine bleeding assays.

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关键词

Poly(acrylic acid),Factor XII autoactivation,Contact activation,Thrombin generation,Murine bleeding assay,Wound bleeding,Hemostatic agent

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