Dynamic Augmentation Of The Left Ventricular Ejection Using Implantable Soft Robotic Device

Introduction: Despite recent technological advances, use of current mechanical circulatory support (MCS) devices often results in thromboembolic complications. Other approaches for therapy of end-stage left heart failure (LHF) such as direct cardiac compression or passive restraint devices have limitations. Hypothesis: We developed an implantable soft robotic device that is anchored to the ventricular septum. When the device actuators contract precisely timed to the native cardiac cycle, the LV free wall is approximated toward the septum, which augments the LV ejection. Methods: The device was tested in adult Yorkshire swine (N=12). LHF was induced by coronary artery ligation and/or Esmolol injection (Group 1, N=6) or by intracoronary injection of 50-100μm microbeads (Group 2, N=6). Aortic and pulmonary flow rate, aortic and left atrial pressures were measured. LV function was assessed using pressure …