Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency

Panojot Bifsha,Jennifer W Leiding,Sung-Yun Pai,Aurelien B L Colamartino,Nicholas Hartog,Joseph A Church,Benjamin R Oshrine,Jennifer M Puck,M Louise Markert,Elie Haddad

Blood Advances（2020）

引用 26|浏览12

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摘要

Key Points 3D organoid T-cell differentiation from a few hundred peripheral blood CD34+ cells was successfully achieved. 3D organoid T-cell differentiation could help physicians distinguish intrinsic from extrinsic defects underlying a clinical SCID phenotype.

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关键词

immune deficiency,diagnostic assay,clinical decisions

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