Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach Edwige Lorthiois , James Roache , David Barnes-Seeman , Eva Altmann , Ulrich Hassiepen , Gordon Turner , Rohit Duvadie , Viktor Hornak , Rajeshri G. Karki , Nikolaus Schiering , Wilhelm A. Weihofen , Francesca Perruccio , Amy Calhoun , Tanzina Fazal , Darija Dedic , Corinne Durand , Solene Dussauge , Kamal Fettis , Fabien Tritsch , Celine Dentel , Adelaide Druet , Donglei Liu , Louise Kirman , Julie Lachal , Kenji Namoto , Douglas Bevan , Rose Mo , Gabriela Monnet , Lionel Muller , Richard Zessis , Xueming Huang , Loren Lindsley , Treeve Currie , Yu-Hsin Chiu , Cary Fridrich , Peter Delgado , Shuangxi Wang , Micah Hollis-Symynkywicz , Joerg Berghausen , Eric Williams , Hong Liu , Guiqing Liang , Hyungchul Kim , Peter Hoffmann , Andreas Hein , Paul Ramage , Allan D'Arcy , Stefanie Harlfinger , Martin Renatus , Simon Ruedisser , David Feldman , Jason Elliott , Richard Sedrani , Juergen Maibaum , Christopher M. Adams Journal of medicinal chemistry（2020）
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